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青岛农业大学-抗氧化和降血糖功效的活性肽

  • 2026-06-04 00:12:13
青岛农业大学-抗氧化和降血糖功效的活性肽
1.专利号：CN121824668A，专利名称：一种具有抗氧化和降血糖功效的活性肽、制剂及应用，申请日：2026.01.23，公布（开）日：2026.04.10，申请人：青岛农业大学
本发明公开了一种具有抗氧化和降血糖功效的活性肽、制剂及应用，属于生物活性肽技术 领域。本发明所述具有抗氧化和降血糖功效的活 性肽的氨基酸序列为FDFL、FGSF、WDRFM中的至少 一种。本发明以小球为原料，分离纯化获得三条 具有抗氧化和降血糖功效的生物活性肽，根据鉴 定出的肽段序列进行化学合成，并对合成的单一 肽段和复配肽段的抗氧化和降血糖功效进行测 定，这些活性肽均具有较好的DPPH清除率、ɑ‑葡 萄糖苷酶和ɑ‑淀粉酶抑制率。因此，这些活性肽 在具有降尿酸和抗氧化功效的产品的开发中具 有重要的应用前景。
1.1权利要求保护范围
1.2相关试验测试
测定超滤获得的不同的分子量的产物的DPPH清除率，结果如图1所示，分子量较小 的< 3KDa的蛋白肽在DPPH清除率的抑制能力上，表现出较好的效果清除率达79.31%。3‑10 kDa为69.85%、>10 kDa为62.31%。 
测定超滤获得的不同的分子量的产物的ɑ‑葡萄糖苷酶及ɑ‑淀粉酶抑制率，结果如 图2所示，显示分子量较小的< 3KDa组分在ɑ‑葡萄糖苷酶抑制率的能力上，表现出较好的抑 制效果抑制率达39.47%，3‑10 kDa为25.15%、>10 kDa为20.27%。不同分子量的组分的ɑ‑淀 粉酶抑制率，结果显示分子量< 3KDa的组分ɑ‑淀粉酶抑制率达66.57%，3‑10 kDa为52.01%、 >10 kDa为44.35%。 
综上，分子量< 3KDa的蛋白肽具有较高抗氧化、降血糖效果。
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  139. /yingpanguazai/ssd/ssd1/www/h.mffb.com.cn/runtime/temp/32b793ebdcbdb96aeb8bb24c123b0bef.php ( 11.98 KB )
  140. /yingpanguazai/ssd/ssd1/www/h.mffb.com.cn/vendor/topthink/think-trace/src/Html.php ( 4.42 KB )
  1. CONNECT:[ UseTime:0.000898s ] mysql:host=127.0.0.1;port=3306;dbname=h_mffb;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000788s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000315s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000297s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000489s ]
  6. SELECT * FROM `set` [ RunTime:0.000194s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000602s ]
  8. SELECT * FROM `article` WHERE `id` = 539541 LIMIT 1 [ RunTime:0.000358s ]
  9. UPDATE `article` SET `lasttime` = 1780686328 WHERE `id` = 539541 [ RunTime:0.005065s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000234s ]
  11. SELECT * FROM `article` WHERE `id` < 539541 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000443s ]
  12. SELECT * FROM `article` WHERE `id` > 539541 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000556s ]
  13. SELECT * FROM `article` WHERE `id` < 539541 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000756s ]
  14. SELECT * FROM `article` WHERE `id` < 539541 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.000798s ]
  15. SELECT * FROM `article` WHERE `id` < 539541 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.000690s ]
0.164968s