南京农业大学学者联合发表《Science》:揭示植物抗病免疫新机制!

近日，国际顶级期刊《科学》（Science）刊发了由南京农业大学、东安格利亚大学及其相关科研研究所、实验室等15位学者联合发表的论文：Surface immune signaling unlocks NLR activation through mRNA alternative splicing.

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标题

Surface immune signaling unlocks NLR activation through mRNA alternative splicing

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摘要

Plants activate pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) to combat pathogens. However, how these systems coordinate immune activation while preventing autoimmunity remains poorly understood. In this study, we uncovered a regulatory mechanism in which surface immune signaling unlocks nucleotide-binding leucine-rich repeat (NLR) immune receptor activation through mRNA splicing. We identified an N-terminal prodomain in the potato late blight resistance protein Rpi-vnt1.1 that inhibits resistosome formation, preventing potential autoactivation of this NLR. Upon pathogen perception, PTI signaling induced alternative splicing of Rpi-vnt1.1 mRNA, removing this inhibitory element. This primed Rpi-vnt1.1 for activation by the Phytophthora infestans effector AVRvnt1, enabling resistosome assembly and immune signaling. The widespread conservation of N-terminal extensions in coiled coil–type NLRs points to a common regulatory mechanism in preventing potential autoactivation while preserving pathogen sensitivity.

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