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吉林农业大学-鹿茸多肽

  • 2026-08-18 07:51:32
吉林农业大学-鹿茸多肽
1.专利号：CN121991161A，专利名称：一种鹿茸多肽及其虚拟酶解制备方法和在抗衰老方面的应用，申请日：2026.01.26，公布（开）日：2026.05.08，申请人：吉林农业大学
本发明属于多肽制备及生物医药技术领域， 具体涉及一种鹿茸多肽及其虚拟酶解制备方法 和在抗衰老方面的应用。本发明中提供的8条鹿茸多肽为从鹿茸蛋白中筛选获得的具备DRP1抑制活性的多肽，具有较高的抗衰老活性，作用机制明确；并且经预测发现，其无毒、无致敏性，且 与DRP1靶点结合能力强，具有良好的成药性和应用安全性，可用于开发抗衰老产品，为新药、保健品或化妆品的研发提供了新的先导化合物。进一 步的，本发明所述鹿茸多肽基于虚拟酶解制备方 法获得，建立了一套完整的、高效的鹿茸抗衰老肽计算机筛选流程，将虚拟酶解、活性预测、安全 性评估和靶向分子对接有机结合，克服了传统分离技术的盲目性，显著提高了筛选效率和成功率。
1.1权利要求保护范围
1.2相关试验测试
1.2.1细胞衰老标志物IL‑6、IL‑1β和TNF‑α含量的变化
可见，与对照组（Control）相比，细胞衰老模型的IL‑6、IL‑1β和TNF‑α的含量显著升高，而抗衰老肽（PNG、ACAL、YR、AYG、GH、NGGF、YG、GR）治疗组均可有效下调其中的IL‑6、 IL‑1β和TNF‑α含量。
1.2.2鹿茸抗衰老肽在衰老动物中的应用
由表6中的结果可知：与对照组（Control）相比，细胞衰老模型的IL‑6、IL‑1β和TNF‑α的含量显著升高，而抗衰老肽（PNG、ACAL、YR、AYG、GH、NGGF、YG、GR）治疗组均可有效下调其中的IL‑6、IL‑1β和TNF‑α含量，与细胞模型的结果一致。
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  1. CONNECT:[ UseTime:0.001008s ] mysql:host=127.0.0.1;port=3306;dbname=h_mffb;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.001364s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000682s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000645s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.001393s ]
  6. SELECT * FROM `set` [ RunTime:0.000526s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.001507s ]
  8. SELECT * FROM `article` WHERE `id` = 570310 LIMIT 1 [ RunTime:0.001410s ]
  9. UPDATE `article` SET `lasttime` = 1787075688 WHERE `id` = 570310 [ RunTime:0.001793s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000638s ]
  11. SELECT * FROM `article` WHERE `id` < 570310 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.001094s ]
  12. SELECT * FROM `article` WHERE `id` > 570310 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000822s ]
  13. SELECT * FROM `article` WHERE `id` < 570310 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.009603s ]
  14. SELECT * FROM `article` WHERE `id` < 570310 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.013193s ]
  15. SELECT * FROM `article` WHERE `id` < 570310 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.001514s ]
0.199680s